approved weight loss drug (contrave)

For the third time in two years, the FDA has approved a drug to help people lose weight. The new drug, Contrave, combines two generic drugs, naltrexone and bupropion.

Naltrexone is used to help kick an addiction to alcohol or narcotics. Bupropion is used to treat depression and seasonal affective disorder. Many people also take bupropion to stop smoking. Neither naltrexone nor bupropion by itself has been approved for weight loss.

How does it work?

Why should the combination of a drug for addiction and one for depression help with weight loss? It’s likely that the drugs act on impulse, reward, and/or hunger centers in the brain to decrease appetite and dampen the reflex to seek food for comfort.

Does Contrave work?

The FDA approved Contrave based on the results of several clinical trials that included 4,500 overweight and obese men and women. Some had significant weight-related conditions, others didn’t. All were treated for one year.

In one trial of people without diabetes, 42% of those who took Contrave lost at least 5% of their body weight, compared with 17% of those who took a placebo. In a trial of people with diabetes, 36% of those taking Contrave lost at least 5% of their body weight, compared with 18 % of those taking a placebo.

Across the studies, some people lost much more than 5% of their body weight. But it’s important to note that more than 50% had minimal or no weight loss.

If Contrave does not work after 12 weeks, the FDA says its use should be stopped.

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