VITAMIN B12

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أعود لكم من بحثي وقراءتي وفضولي في علم التغذية

اليوم راح اتكلم عن فيتامين مهم جدا وكتير اشوف في الطواريء يعطو للمرضى اللي يعانون من الإرهاق

بس ما فكرت ولا مرة كيف ممكن نعطيه او كيف يشتغل دا الفيتامين او كيف نحلل في الدم

رغم اني اعتبر الكلام في موضوع الفيتامينات تقليدي جدا، ولكن الكم الهائل من المعلومات التي وجدتها هي التي اجبرتني على كتابة الموضوع

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Vitamin B12 is also known as cyanocobalamin or methylcobalamin.

Benefit of B12

1-helping with DNA and energy production.

2-B12 is also necessary for proper red blood cell (RBC) formation

3-neurological and brain function

4-and protein and fat metabolism.

B12 deficiency symptoms include

• Deficiency is primarily due to issues of malabsorption(GI disease or surgery)

• poor dietary intake and pernicious anemia

• Rates of deficiency increase with age

• Megaloblastic anemia

• Fatigue and weakness

• Constipation

• Loss of appetite and weight loss

• Numbness and tingling in hands and feet

• Poor balance

• Poor memory and dementia

• Mouth or tongue soreness

• Depression

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Malabsorption

1-GI disorders like celiac disease and inflammatory bowel disease (IBD) GI 2-surgery, like removal of intestines or gastric bypass.

Pernicious Anemia

1-autoimmune disease that destroys stomach cells

2-reduces the body’s ability to produce intrinsic factor

3-A lack of B12 leads to reduced red blood cells.

what is intrinsic factor??!

Produced by the parietal cells of the stomach as well as the salivary glands, intrinsic factor is key for supporting energy, metabolism, and mental health by working with one nutrient—vitamin B12

intrinsic factor يعتبر اهم مركب في جسم الإنسان ولا يشتغل الا في وجود فيتامين ب١٢ فعند حصول نقص في هذا الفيتامين فراح يحصل خلل في intrinsic factor فبالتالي يحصل pernicious anemia

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من أهم النقاط للتشخيص على النقص هو التحليل ، وكثير يجي في بال البعض تحليل فيتامين ب١٢ ولكن هذه معلومة خاطئة ،هناك ٤ تحاليل عشان تحدد النقص في فيتامين ب١٢ ، واهم شي على الاقل نعمل تحليلين عشان نحدد مزبوط

1- Typically, plasma or serum B12 levels are measured

reference range : 118 and 701 mmol/dL.

Unfortunately, this measure doesn’t show the level of B12 within cells and has a low predictive ability التحليل هذا غير دقيق

2-Levels of homocysteine, an amino acid that can cause inflammation of blood vessels when elevated, helps predict B12 status as well.

reference range: 4 -14 mmol/l

دا افضل تحليل يحدد النقص إذا ارتفع منسوبه في الدم فمعناه في نقص في ب١٢

3-Urinary or plasma methylmalonic acid (MMA)

4-Holotranscobalamin (holoTC) reflects B12 levels in the body too

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وظائف إضافية لفيتامين ب١٢ بعد الشرح

1-help metabolize homocysteine levels. Still, it’s not clear whether B12 supplementation can reduce the risk of heart disease directly

2- B12 has been shown to slow down the replication of the hepatitis C virus. When patients with hepatitis C were given standard therapy or standard therapy with a B12 injection of 5,000mcg, every 4 weeks for 48 weeks, those with the additional B12 responded better to treatment

3- B12 has also been proven to reduce the risk of acute lymphoblastic leukemia in children when pregnant mothers supplement during the last six months of pregnancy

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Foods High in Vitamin B12

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Supplementation B 12

B12 supplements are typically present in the cyanocobalamin form, which must be converted in the body to active-B12, methylcobalamin and 5-deoxyadenosylcobalamin.

• sublingual (under the tongue) vitamin B12 has been given daily for six months.Five hundred micrograms of sublingual (under the tongue) vitamin B12 has been used daily for up to four weeks

• Intramuscular B12 injections can also be used. Some don’t prefer this route as it requires a medical professional to administer. However, in cases of severe nutrient malabsorption and pernicious anemia, injections are more efficient at correcting the deficiency. One 1,000 microgram vitamin B12 injection has been used daily for five days, followed by one 1,000 microgram injection monthly for five months. Additionally, 1000 microgram injections have been used weekly for four weeks or monthly for six months.

• There are also gel formulations of B12, available as a prescription medication, that is applied to the inside of the nose. While this is an effective method, it hasn’t been carefully studied in clinical trials

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اخر شي احب اقوله دائما، اوقات اكتب معلومات قد تكون جديدة علي او على البعض ولكن تكون قديمة لدى البعض الآخر فلا يعني ذلك عدم نشرها ، احب نشر المعلومة سواء قديمة او جديدة

واتمنى ان يكون الموضوع نال على استحسانكم

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